ABSTRACT
Objective To evaluate the clinical efficacy of oral ulcer protective agent in the prevention and treatment of oral mucositis in nasopharyngeal carcinoma (NPC) radiotherapy and its effect upon serum inflammatory factors.Methods A total of 90 patients diagnosed with nasopharyngeal carcinoma presenting with grade I oral mucositis caused by radiotherapy in our hospital were selected and randomly divided into two groups.In the experimental group,oral ulcer protective agent was given,and Kangfuxin gargle was administered in the control group.The incidence time and degree of radioactive oral mucositis,visual analogue scale (VAS) pain score,serum levels of CRP,TGF-β1,IL-6 and T lymphocyte subsets were statistically compared between two groups by independent-sample t-test.Results At 4 and 6 weeks after corresponding treatment,the incidence of grade Ⅱ and Ⅲ oral mucositis in the experimental group was significantly lower than that in the control group (P=0.018,0.021,0.027,0.014)).In the experimental group,the incidence of moderate and severe pain assessed by VAS was significantly lower compared with that in the control group (P=0.019,0.025);After corresponding treatment,the CRP levels in both groups were down-regulated and the CRP level in the experimental group was considerably lower than that in the control group (P=0.013).The levels of TGF-β1 and IL-6 in the control group were significantly increased (P=0.015、0.021),whereas dramatically declined in the experimental group (P=0.012,0.019).CD3(+),CD4 (+),CD8(+) and CD4(+)/CD8(+) were remarkably elevated in two groups,and more significant increase was observed in the experimental group (P=0.024,0.036,0.029,0.017).Conclusions Oral ulcer protective agent can effectively inhibit the progression of oral mucosal injury,shorten the healing time and relieve the pain of oral mucosal injury in patients with NPC.,which is worthy of clinical application.
ABSTRACT
BACKGROUND: Mesh plug tension-free hernioplasty is commonly used for inguinal hernia. In the operation, different mesh materials can be selected, among which the modified Kugel mesh is extensively applied. OBJECTIVE: To observe the biocompatibility of modified Kugel mesh in mesh plug tension-free hernioplasty for inguinal hernia. METHODS: Total y 79 cases of inguinal hernia were treated by mesh plug tension-free hernioplasty. The patients were randomly divided into observation group repaired with Bard mesh (modified Kuge) (n=38) and control group repaired with Prolene mesh (n=41). After 12-month fol ow-up, levels of interleukin 6, C-reactive protein and tumor necrosis factor α were detected and compared before and after treatment;adverse events, including wound infection or infection caused by the mesh in the two groups were recorded. RESULTS AND CONCLUSION: Levels of interleukin 6, C-reactive protein and tumor necrosis factor α in the two groups were significantly decreased after treatment than before treatment (P < 0.05). No wound infection or infection caused by the mesh appeared in both two groups. Although scrotum effusion occurred in two cases of each group, their outcomes al improved significantly after active puncture and suction treatment without other serious problems. No recurrence was found during the 12-month fol ow-up. These results show that the modified Kugel mesh has good biocompatibility in mesh plug tension-free hernioplasty for inguinal hernia.